Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8300630 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2012 | 13 Pages |
Abstract
⺠Mitochondrial DNA is susceptible to endogenous and environmental damage. ⺠Mitochondria lack the full cohort of nuclear DNA repair mechanisms. ⺠Persistent mtDNA damage poses a threat to mitochondrial gene expression. ⺠Mitochondrial polymerase disruption by mtDNA damage may underlie human disease and environmental toxicity.
Keywords
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Authors
Susan D. Cline,