| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300727 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2018 | 11 Pages |
Abstract
HIV infection and its proteins are known to disrupt physiological differentiation of MSC; increased gp120-driven migration amplifies the total MSC population destined for ineffective and inappropriate differentiation, thus contributing to the pathogenesis of HIV-related comorbidities. Additionally, given that MSCs are permissive to HIV infection, initial cellular priming by gp120 results in increased expression of CXCR4 and could lead to co-receptor switching and cell tropism changes in chronic HIV infection and may have implications against CCR5-knockout based HIV cure strategies.
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Authors
Lei Li, Ryan Z.L. Lim, Lawrence S.U. Lee, Nicholas S.Y. Chew,