| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300772 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2018 | 52 Pages |
Abstract
We conclude that LGM2605 inhibits MPO activity by suppressing both the peroxidase and chlorination cycles. EPR analysis demonstrated that LGM2605 inhibits MPO by decreasing the formation of the highly oxidative Compound I. This study identifies a novel mechanism of LGM2605 action as an inhibitor of MPO and indicates that LGM2605 may be a promising attenuator of oxidant-dependent inflammatory tissue damage.
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Authors
Om P. Mishra, Anatoliy V. Popov, Ralph A. Pietrofesa, Eiko Nakamaru-Ogiso, Mark Andrake, Melpo Christofidou-Solomidou,