Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models

Article ID	Journal	Published Year	Pages	File Type
8300876	Biochimica et Biophysica Acta (BBA) - General Subjects	2018	50 Pages	PDF

Abstract

Matrix vesicles are extracellular vesicles that bind to collagen and can induce formation of apatitic mineral during physiological and ectopic mineralization. Lipid and protein compositions in matrix vesicles resemble those of lipid rafts. Mechanisms of the biogenesis of matrix vesicles and processes leading to mineral/apatite formation are still unclear. Proteoliposomes can serve as biomimetic models to understand matrix vesicle-mediated mineralization.122

Keywords

EVS FFA PPI ACP DPPC MAG ECM TLR GPi IL-1beta PiT-1 OPN IVS Cryo-EM VSMCs monoacylglycerol DOPC MVS ANK TNAP PHOSPHO1 CPPD DPPS TSG101 UCC OMFS EXS PMVS ACVs OCP AFM ABS Mmps BCP CHOL Rheumatoid arthritis Tissue-nonspecific alkaline phosphatase Ankyrin ectonucleotide pyrophosphatase/phosphodiesterase 1 Osteoarthritis Osteopontin sphingomyelin Free fatty acid standard deviation octacalcium phosphate Exosomes Tem Interleukin-1 beta Apoptotic bodies triacylglycerol TAG یا triacylglycerols Toll-like receptor Extracellular vesicles calcium pyrophosphate dihydrate dioleoylphosphatidylcholine dipalmitoylphosphatidylserine dipalmitoylphosphatidylcholine DAG Vascular smooth muscle cells Plasma membrane vesicles Enrichment inorganic phosphate Amorphous calcium phosphate Basic calcium phosphate phosphatidylinositol phosphatidylcholine phosphatidylethanolamine Phosphatidylserine Lipid raft Matrix vesicles Extracellular matrix Matrix metalloproteinases BMP not determined Mineralization MicroRNA MiRNA Electron microscopy Transmission electron microscopy Cryo-electron microscopy atomic force microscopy wild-type Proteoliposomes Bone morphogenetic protein inorganic pyrophosphate Tumor susceptibility gene 101 cholesterol glycosylphosphatidylinositol