| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300911 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2018 | 42 Pages |
Abstract
Our results show that PPI inhibits growth of CRPC cells through inhibition of HOTAIR expression, subsequently; this results in the repression of DNMT1 and EZH2 expressions. The interactions among HOTAIR, DNMT1 and EZH2, and reciprocal regulation of DNMT1 and EZH2 contribute to the overall responses of PPI. This study reveals a novel mechanism for HOTAIR-mediated regulating DNMT1 and EZH2 in response to PPI in inhibition of the growth of CRPC cells.
Keywords
NF-κBPolyphyllin IDNA methyltransferase 1HOX transcript antisense RNASEAPPRC2EZH2DNMTsCRPCDnmt1NPCADTCDKlncRNAqRT-PCRmiRNAsPPI3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromideDMSOMTTlong non-coding RNASecreted alkaline phosphatasebioluminescence imagingBLIandrogen deprivation therapydimethylsufoxideCastration-resistant prostate cancernuclear factor-kappaBHOTAIRpolycomb repressive complex 2Nasopharyngeal carcinomacyclin dependent kinase
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Authors
SongTao Xiang, PeiLiang Zou, Qing Tang, Fang Zheng, JingJing Wu, ZhiQiang Chen, Swei Sunny Hann,