| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300978 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2017 | 40 Pages |
Abstract
Thus far, only little information is available on the significance and role of miRNAs with respect to kinase inhibitor treatments and emergence of drug resistance. In this study, promising miRNAs and genes were identified and associated to BRAF inhibitor-mediated resistance in melanoma. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue.
Keywords
chemokine C-C motif ligand 2Sesn2cysteine-rich angiogenic inducer 61CHAC1PC2Cyr61DcTAsnSMITFCTLA4BRAFHRENF1cytotoxic T-lymphocyte associated protein 4HIF-1αneuroblastoma RAS viral oncogene homologNRASCCL2PCSK2MAPKPCAasparagine synthetaseAxldopachrome tautomerasePrinciple component analysisEMTMelanomaTargeted therapySestrin 2hypoxia-inducible factor 1αHypoxia-response elementMicrophthalmia-associated transcription factorDrug resistanceBRAF inhibitorsMiRNANeurofibromin 1mitogen activated protein kinaseEpithelial-mesenchymal transition
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Authors
Ines Kozar, Giulia Cesi, Christiane Margue, Demetra Philippidou, Stephanie Kreis,