Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8300980 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2017 | 32 Pages |
Abstract
Production of Cas8b generates a small C-terminal fragment, which is suggested to fulfill the role of the missing small subunit. A heterologous, synthetic M. maripaludis Type I-B system is active in E. coli against phage lambda, highlighting a potential for genome editing using endogenous Type-I-B CRISPR-Cas machineries. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue.
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Authors
Hagen Richter, Judith Rompf, Julia Wiegel, Kristina Rau, Lennart Randau,