Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors

Article ID	Journal	Published Year	Pages	File Type
8300981	Biochimica et Biophysica Acta (BBA) - General Subjects	2017	16 Pages	PDF

Keywords

hDHFR DTMP PTR1 Human dihydrofolate reductase Trypanosomatids Leishmania infantum MTX Trypanosoma brucei FOL HTS THF dhfr Trypanosoma cruzi deoxythymidine monophosphate deoxyuridine monophosphate dihydrofolate reductase dUMP thymidylate synthase MIF Structure-based drug design Folate Leishmania donovani Leishmania major Methotrexate Folate pathway Selective inhibition Enzyme inhibitor PABA Pteridine reductase 1

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors

Authors

Joanna Panecka-Hofman, Ina Pöhner, Francesca Spyrakis, Talia Zeppelin, Flavio Di Pisa, Lucia Dello Iacono, Alessio Bonucci, Antonio Quotadamo, Alberto Venturelli, Stefano Mangani, MariaÂ Paola Costi, Rebecca C. Wade,