Inflammatory cell signaling following exposures to particulate matter and ozone

Article ID	Journal	Published Year	Pages	File Type
8301011	Biochimica et Biophysica Acta (BBA) - General Subjects	2016	47 Pages	PDF

Abstract

Cellular signaling plays a critical role in the regulation of inflammatory pathogenesis. Elucidation of cellular signaling pathways initiated by PM or O3 cannot only help to uncover the mechanisms of air pollutant toxicity but also provide clues for development of interventional measures against air pollution-induced disorders. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu.

Keywords

8-OHdG VOCs HB-EGF Heme oxygenase-1 TGF PM2.5 AP-1 GPCRs EGFR PTP MYD88 TACE DEP ERK Nrf2 PAMPs GST GPX ICAM-1 HO-1 COX-2 AHR mitogen-activated protein kinase phosphatase 1 UGT1A6 PM0.1 MAPKKK NF-κB PI3K MAPKK EGF c-Src Residual Oil Fly Ash NOD LPS MKP-1 NQO1 PRRs VCAM-1 DAMPs CXCL 8-hydroxy-2′-deoxyguanosine G-protein coupled receptors MAPKs NOx PM2.5–10 ROS TLRs tumor necrosis factor-α-converting enzyme Akt inflammation damage-associated molecular patterns pathogen-associated molecular patterns Ozone Oxides of nitrogen interleukin COPD Chronic obstructive pulmonary disease transforming growth factor Volatile organic compounds tumor necrosis factor-α nucleotide-binding oligomerization domain Diesel exhaust particles particulate matter SOD ROFA Superoxide dismutase Cyclooxygenase-2 Cell signaling epidermal growth factor antioxidant response element Heparin-binding EGF-like growth factor TNF-α nuclear factor (erythroid-derived 2)-like 2 nuclear factor-κB phosphoinositide 3-kinase lipopolysaccharide CXC chemokine ligand intercellular adhesion molecule-1 Vascular adhesion molecule-1 ARE Hyaluronan Polycyclic aromatic hydrocarbons PAHs Airway hyperresponsiveness Protein tyrosine phosphatase activator protein-1 protein kinase B mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase kinase extracellular signal-regulated kinase mitogen-activated protein kinases glutathione peroxidase Reactive oxygen species Epidermal growth factor receptor pattern recognition receptors Toll-like receptors