A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2Â + under physiologically relevant conditions

These findings indicate that the requirement of an enzyme to oxidize iron may only be necessary under conditions of adverse pH or anionic strength, for example from hypoxia. In a normal physiological environment, Fe3 + incorporation into transferrin would be sufficiently enabled by the biological polyanions that are prevalent within extracellular fluids.