| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301158 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 8 Pages |
Abstract
⺠We aimed to evaluate the combination effect of pleurocidin with antibiotics. ⺠Most combinations between pleurocidin and antibiotics showed synergistic effects. ⺠We investigated the mechanism(s) involved in the synergistic effects. ⺠The synergisms were induced by hydroxyl radical production and membrane damage. ⺠Additionally, we indentified that pleurocidin exerted antibiofilm effect.
Keywords
PBSCH3CNBHIAMPsCLSINCCLshpfPleurocidinMICTissue culture platePESEPSPleuronectes americanusFICIMTTMembrane damageSynergistic effectAcetonitrileBrain–Heart infusionMinimum inhibitory concentrationHydroxyl radicalFractional inhibitory concentration indexPhosphate buffered salinephenazine ethosulfateTCPLuria BertaniExtracellular polymeric substanceClinical and Laboratory Standards InstitutePropidium iodideAntimicrobial peptidesNational Committee for Clinical Laboratory Standards
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Authors
Hyemin Choi, Dong Gun Lee,