| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301163 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 10 Pages |
Abstract
⺠This is the first report on photochemical internalization (PCI) of a HER2-targeted immunotoxin. ⺠Synergistic cytotoxicity of PCI of trastuzumab-saporin in trastuzumab-resistant Zr-75-1 cells ⺠Photochemical effects on HER2-mediated endocytosis with impact on PCI on trastuzumab-saporin ⺠PCI effect only observed when the immunotoxin is administered prior to the photochemical treatment ⺠PCI of trastuzumab-saporin; a method to treat HER2 + and trastuzumab-resistant breast cancer
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Authors
Maria Brandal Berstad, Anette Weyergang, Kristian Berg,