| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301175 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 7 Pages |
Abstract
⺠Cyclophilin A (CyPA) and B (CyPB) activated HCV RNA polymerase (RdRp). ⺠CyPA activated all the HCV RdRps so far tested. ⺠CyPA activation required 50 à higher amount than that of RdRp. ⺠CyPB activated genotype 1b and J6CF RdRps but not genotype 1a or JFH1 RdRps. ⺠CyPB showed allosteric effect on the HCV RdRp activation.
Keywords
SVRcyclophilin BCyPpegylated interferon-αDTTRdRpPEG-IFNCyclophilin APMSFGSTRT-PCRPPIBSAphenylmethanesulfonylfluorideRNA-dependent RNA polymeraseRNA polymerasebovine serum albuminEDTAEthylenediaminetetraacetic acidSDS-PAGECSAdithiothreitolCyclosporine Acyclophilinnonstructural proteinwild typeHCVHepatitis C virusreverse transcription polymerase chain reactionsustained virological responseEnvelopeglutathione S-transferase
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Authors
Leiyun Weng, Xiao Tian, Yayi Gao, Koichi Watashi, Kunitada Shimotohno, Takaji Wakita, Michinori Kohara, Tetsuya Toyoda,