Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

Article ID	Journal	Published Year	Pages	File Type
8301187	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	14 Pages	PDF

Abstract

âº Zoledronate inhibits invasion, migration and adhesion of breast cancer cells. âº Modulates the expression of matrix molecules implicated in cancer progression. âº Potent pharmaceutical anticancer agent for breast cancer.

Keywords

membrane-type MMP Tissue inhibitors of MMPs Col II MMP TIMPs Col-IV MT-MMP BPS ECM Zoledronate FAK Bisphosphonates Tenascin Invasion ZOL Breast cancer Fibronectin Laminin Extracellular matrix matrix metalloproteinase Migration Hyaluronan Vitronectin Proteoglycan Adhesion Col I Collagen II Collagen IV Collagen I focal adhesion kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

Authors

P.G. Dedes, Ch. Gialeli, A.I. Tsonis, I. Kanakis, A.D. Theocharis, D. Kletsas, G.N. Tzanakakis, N.K. Karamanos,