| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301217 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 10 Pages |
Abstract
⺠We have performed a functional analysis of leishmanial DNA topoisomerase IB. ⺠Constructs were assayed on relaxation activity and sensitivity to camptothecin. ⺠Amino acids 175 to 180 of the small subunit play a pivotal role in enzyme activity. ⺠RPPVV pentapeptide motif is responsible for CPT sensitivity in the small subunit.
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Authors
Christopher F. Prada, Raquel Álvarez-Velilla, Rosario Diaz-González, Carlos Prieto, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M. Reguera,