| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301232 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2018 | 46 Pages |
Abstract
Summary of the main findings of this manuscript. Oxaliplatin and 5-FU activate p53, induce autophagy and inhibit mitochondrial respiration. Both processes are influenced by CerS5 which impacts chemosensitivity of p53wt expressing colon cancer cells.110
Keywords
LUCqRT-PCRFB1PolyadenylationCOAAP-1shRNAECARS1PDTTLC3BGFPDSSOCRMMP-1EMDCerSWSTwater-soluble tetrazoliumnSMase5-FULacCerdhCerCREBRPL37A3′-UTRAUCLC-MS/MSshort hairpin RNASp1Sphingosine-1-phosphatesphingolipidneutral sphingomyelinaseSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisEmerinOxaliplatinempty vectoranalysis of varianceANOVAstandard error of the meanUntreatedDihydroceramidedithiothreitolCerceramideceramide synthasethree prime untranslated regionDextran sulfate sodium5-fluorouracilFumonisin B1lactosylceramideluciferaseMatrix metalloproteinase-1SEMSpecificity protein 1area under the curveOxygen consumption rateMicroRNAextracellular acidification ratequantitative real-time polymerase chain reactionCREB binding proteinactivator protein 1green fluorescent proteincAMP response element-binding proteinPropidium iodidepoly(A)liquid chromatography coupled to tandem mass spectrometryChloroquineChemoresistancenegative controlcoenzyme Aglucosylceramide
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Authors
Sebastian Brachtendorf, Ruth Anna Wanger, Kerstin Birod, Dominique Thomas, Sandra Trautmann, Marthe-Susanna Wegner, Dominik C. Fuhrmann, Bernhard Brüne, Gerd Geisslinger, Sabine Grösch,