Article ID Journal Published Year Pages File Type
8301240 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2018 37 Pages PDF
Abstract
This indicates that PGE2 suppression of TNF-α by human monocytic cells occurs via EP2R and EP4R expression. However EP4Rs also control their own expression and that of EP2 whereas the EP2R does not affect EP4R expression. This implies that EP4 receptors have an important master role in controlling inflammatory responses.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
The prostaglandin EP4 receptor is a master regulator of the expression of PGE2 receptors following inflammatory activation in human monocytic cells
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