| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301378 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2018 | 13 Pages |
Abstract
Proposed mechanism by which AdipoQ AS lncRNA inhibits adipogenesis. A) In vitro effect and molecular mechanism of AdipoQ AS lncRNA. AdipoQ AS lncRNA transfers from nucleus to cytoplasm, inhibiting adipogenic differentiation through forming a sense/antisense RNA duplex to prevent translation of AdipoQ mRNA. B) In vivo effect of AdipoQ AS lncRNA. AdipoQ AS lncRNA and NOR decrease the WAT, BAT and liver TG in HFD mice, but NOR improves the GTT and ITT.189
Keywords
FFAseWATADIPOQBATPRDM16IRSPPARγRNA duplexAP2HFDNORGTTRPACpt1αHSLRNA-seqIWATSREBP1cTNFαPGC1-αCPCC/EBPαCCAAT/enhancer binding protein αUcp1adiponectinAdipogenesisinsulin tolerance testRibonuclease protection assayAtglFree fatty acidsinsulin receptor substrateITTepididymal white adipose tissueinguinal white adipose tissuebrown adipose tissueRNA sequencingtriglycerideglucose tolerance testtumor necrosis factor αHigh fat dietfluorescence in situ hybridizationadipose triglyceride lipasehormone sensitive lipaseCoding Potential CalculatorFishLipid metabolismHalf-lifefatty acid binding protein 4uncoupling protein 1insulin receptorperoxisome proliferator activated receptor γ
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Authors
Rui Cai, Yunmei Sun, Naren Qimuge, Guoqiang Wang, Yingqian Wang, Guiyan Chu, Taiyong Yu, Gongshe Yang, Weijun Pang,