| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8301679 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2016 | 10 Pages |
Abstract
Our results suggest that exposure to excess dietary fat during early and post-natal life increases the susceptibility to develop NASH in adulthood, involving altered cellular redox status, reduced sirtuin abundance, and desynchronized clock gene expression.
Keywords
Sirt1cryptochrome 2SREBP1cNAFLDCry2Sirtuin 3RORαOPNsirtuin 1Sirt3Per2Non-alcoholic steatohepatitisOsteopontinnon-alcoholic fatty liver diseasecircadianDevelopmentMaternal dietClockAgingNADNash nicotinamide adenine dinucleotideSterol regulatory element binding protein-1chigh fatcircadian locomotor output cycles kaputFatty liverControl
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Authors
Kimberley D. Bruce, Dawid Szczepankiewicz, Kiran K. Sihota, Manoj Ravindraanandan, Hugh Thomas, Karen A. Lillycrop, Graham C. Burdge, Mark A. Hanson, Christopher D. Byrne, Felino R. Cagampang,