Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8301712 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2016 | 31 Pages |
Abstract
Ceramide 1-phosphate (C1P) is a phosphosphingolipid with potent biological activities. It promotes cell growth and survival, and is a key regulator of cell migration. Both C1P and the enzyme that catalyzes its biosynthesis, ceramide kinase, are implicated in inflammatory responses. Although C1P has pro-inflammatory properties, it reduces pulmonary emphysema and exerts anti-inflammatory actions in the lung. Synthetic C1P analogs may be promising tools to treat lung inflammation.
Keywords
PI3KCERKC1PAkt (PKB)SphKBMDMGLUTSMaseS1PPTXPKCcPLA2SPTERKMCP-1iNOSROSsphingolipidsSphingosine kinasesphingomyelinaseArachidonic acidphosphatidic acidinflammationGlucose transporterceramidesCeramide 1-phosphateCeramide kinaseserine palmitoyl transferasepertussis toxininducible nitric oxide synthasePhosphatidylinositol 3-kinaseBone marrow-derived macrophagesCell migrationmonocyte chemoattractant protein-1Protein kinaseProtein kinase CReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Natalia Presa, Ana Gomez-Larrauri, Io-Guané Rivera, Marta Ordoñez, Miguel Trueba, Antonio Gomez-Muñoz,