Disruption of the mevalonate pathway induces dNTP depletion and DNA damage

Article ID	Journal	Published Year	Pages	File Type
8301895	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2015	50 Pages	PDF

Keywords

dNTP 7-hydroxystaurosporine E2 transcription factor DNS Deoxyribonucleosides ss-DNA UCN-01 NDP E2F deoxyribonucleotides RNR MVD IPP DMAPP PBS ACN THF NGS TCA Mevalonate 5-bromo-2′-deoxyuridine Single-stranded DNA DNA damage Acetonitrile trichloroacetic acid Phenylacetic acid isopentenyl diphosphate BrdU Tetrahydrofurane deoxyribonucleoside triphosphate Nucleoside diphosphate dimethylallyl diphosphate Ribonucleotide reductase normal goat serum LDL low-density lipoproteins Phosphate-buffered saline Hydroxyurea retinoblastoma protein cholesterol

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Disruption of the mevalonate pathway induces dNTP depletion and DNA damage

Authors

Covadonga MartÃn Sánchez, José Manuel Pérez MartÃn, Jong-Sik Jin, Alberto Dávalos, Wei Zhang, Gema de la Peña, Javier MartÃnez-Botas, Sara RodrÃguez-Acebes, Yajaira Suárez, MarÃa José Hazen, Diego Gómez-Coronado, Rebeca Busto,