Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8302291 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 | 6 Pages |
Abstract
The mechanisms that co-ordinately activate lipid synthesis when high rates of membrane biogenesis are needed to support cell growth are largely unknown. c-Fos, a well known AP-1 transcription factor, has emerged as a unique protein with the capacity to associate to specific enzymes of the pathway of synthesis of phospholipids at the endoplasmic reticulum and activate their synthesis to accompany genomic decisions of growth. Herein, we discuss this cytoplasmic, non-genomic effect of c-Fos in the context of other mechanisms that have been proposed to regulate lipid synthesis.
Keywords
AP-1CDP-diacylglycerol synthasePap11-Acylglycerol-3-phosphate O-acyltransferaseAGPATbasic domainPtdInsGPATGlcCerPPIsNGFPISASOPSSCCTCTP:phosphocholine cytidylyltransferaseantisense oligonucleotideFörster resonance energy transferFRETCNSleucine zippercentral nervous systemperipheral nervous systemendoplasmic reticulumnerve growth factorphosphatidylinositolphosphatidylcholinephosphatidylethanolaminePhosphatidylserinePhosphatidylserine synthasePhosphatidylinositol synthaseactivator protein-1CdSPNSglucosylceramide
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Authors
Beatriz L. Caputto, Andrés M. Cardozo Gizzi, Germán A. Gil,