| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302531 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 11 Pages |
Abstract
Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the functional properties of lipids. For instance, ceramide acts as a strong tumor suppressor that causes apoptosis and cell cycle arrest, while GlcCer has an opposite effect, downregulating ceramide activities. All glucosylated lipids are enriched in lipid rafts or microdomains and play fundamental roles in a variety of cellular processes. In this review, we discuss the biological functions and metabolism of these three glucosylated lipids.
Keywords
AMPKCERTα-GalCerCerSPKDLDSVAPGSLGlcCerGalCerGTFABCA12GBAGPiSPTHspGCaseLPSUGCGglycosphingolipidVesicle-associated membrane protein-associated proteinConduritol B epoxidecoat protein complex IIPtdEthCBEPtdChoPtdInsAMP-activated protein kinasePtdIns(4)Pinvariant natural killer T cellsα-galactosylceramideDIMsphingolipidsphingomyelin synthaseacid β-glucosidasephosphatidic acidpolycystic kidney diseaseSaposin Cserine palmitoyl transferaseiNKT cellsceramide synthaseendoplasmic reticulumstartMass spectrometryphosphatidylinositolphosphatidylcholinePhosphatidylglucosidephosphatidylethanolamineLipid dropletslipopolysaccharideBMPPleckstrin Homologyceramide transport proteinHeat shock proteinSMSCOPIIgalactosylceramideUDP-glucoseuridine diphosphate glucoseglucosylceramideGlucosylationglucocerebrosidaseglycosylphosphatidylinositolglycolipid
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Authors
Yohei Ishibashi, Ayako Kohyama-Koganeya, Yoshio Hirabayashi,