| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302648 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 11 Pages |
Abstract
⺠Short chain ceramides inhibited iNOS and proinflammatory cytokines in microglia. ⺠C2 ceramide suppressed microglial activation in the brain of septic mice. ⺠C2 ceramide inhibited ROS, MAPKs, PI3K/Akt and Jak/STAT pathways. ⺠C2 ceramide upregulated PKA and hemeoxygenase-1 expressions. ⺠C2 ceramide inhibits TLR4 signaling by interfering with LPS and TLR4 interactions.
Keywords
MMPC1PLPSnSMaseCREASMaseNrf2TLR4HO-1Heme oxygenase-1S1PiNOSROSacidic sphingomyelinaseSphingosine-1-phosphateneutral sphingomyelinaseNeuroinflammationCeramide-1-phosphateinducible nitric oxide synthaseantioxidant response elementcAMP responsive elementlipopolysaccharidematrix metalloproteinasemolecular mechanismMicrogliaAREReactive oxygen species
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Authors
Ji-Sun Jung, Kyong-Oh Shin, Yong-Moon Lee, Jin A. Shin, Eun-Mi Park, Jinju Jeong, Dong-Hyun Kim, Ji Woong Choi, Hee-Sun Kim,