| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302655 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 10 Pages |
Abstract
⺠PPARγ regulates CIC expression during fibroblast differentiation into fat cells. ⺠Activated PPARγ up-regulates CIC expression in fibroblasts, but not in adipocytes. ⺠In fibroblasts PPARγ ligand enhances the recruitment of PPARγ/Sp1/PGC1αãARA70 coactivators to CIC promoter. ⺠In adipocytes PPARγ/Sp1/SMRT corepressor are recruited on CIC promoter. ⺠Divergent effects of PPARγ on CIC expression during adipogenesis are proposed.
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Authors
Daniela Bonofiglio, Antonella Santoro, Emanuela Martello, Donatella Vizza, Daniela Rovito, Anna Rita Cappello, Ines Barone, Cinzia Giordano, Salvatore Panza, Stefania Catalano, Vito Iacobazzi, Vincenza Dolce, Sebastiano Andò,