Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8302671 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 10 Pages |
Abstract
⺠Arg403 is important for structural integrity of 12/15-LOX. ⺠Side-chain of Arg403 contributes to stability of LOX's tertiary structure. ⺠Substrate binding to Arg403 might be associated with α2-helix rearrangement. ⺠Mutation of Arg403 leads to distortion of catalytic properties of LOX enzyme.
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Authors
Almerinda Di Venere, Thomas Horn, Sabine Stehling, Giampiero Mei, Laura Masgrau, Ãngels González-Lafont, Hartmut Kühn, Igor Ivanov,