| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302762 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 18 Pages |
Abstract
⺠Mitochondrial oxidative capacity in white fat correlates negatively with adiposity. ⺠Energy is required for futile fatty acid cycling (TAG/FA cycle) in adipocytes. ⺠Stimulation of TAG/FA cycle is associated with the induction of β-oxidation in adipocytes. ⺠TAG/FA-mediated energy expenditure (EE) may reduce adiposity and lipotoxicity. ⺠Physiological interventions may induce UCP1-independent EE in white fat.
Keywords
CB1FASOXPHOSlong-chain n-3 polyunsaturated fatty acidsMCP-1PPARγBATAMPKPPARCTRP3PD1PEPCKFGF-21HSL15d-PGJ2TZDPGC-1LPSfatty acid translocase/CD36PDK4Sirt1SREBP-1cACCProtectin D1EPA15-deoxy-Δ12,14-Prostaglandin J2AMP-activated protein kinaseMitochondrial DNAFAT/CD36Ucp1branched-chain amino acidsacetyl-CoA carboxylaseArachidonic acidEicosapentaenoic aciddocosahexaenoic acidfatty acid synthaseFatty acidsOmega 3Adipose tissueWhite adipose tissuebrown adipose tissueBCAATriacylglycerolsTAG یا triacylglycerols ThiazolidinedioneATMDHAmtDNAFibroblast growth factor-21phosphoenolpyruvate carboxykinaseOxidative phosphorylationhormone-sensitive lipaselipopolysaccharideadipose tissue macrophagescalorie restrictionObesityLipid mediatormonocyte chemoattractant protein-1sterol regulatory element-binding protein-1cPyruvate dehydrogenase kinase 4pyruvate carboxylasehigh-fatWATperoxisome proliferator-activated receptorcannabinoid type-1 receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Pavel Flachs, Martin Rossmeisl, Ondrej Kuda, Jan Kopecky,