Phospholipid metabolism and nuclear function: Roles of the lipin family of phosphatidic acid phosphatases

► Phospholipids play critical roles in nuclear structure and function. ► The lipin PA phosphatases localize to the cytoplasm and nucleus of many cell types. ► Lipins regulate gene expression of lipid metabolic enzymes through multiple mechanisms. ► Lipins play critical roles in nuclear architecture in many eukaryotes. ► Nuclear lipins may be important for the maintenance of cellular lipid homeostasis.