| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302958 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 9 Pages |
Abstract
⺠We polarize human monocyte-derived macrophages (MDMs) to various sub-phenotypes. ⺠We test the propensity of different MDM sub-phenotypes to accumulate cholesterol. ⺠IFNγ or TNFα treatment reduces total cholesterol accumulation. ⺠Treatment with either IFNγ or TNFα reduces the expression of both CD36 and SR-AI. ⺠IFNγ attenuates the PPARγ-mediated upregulation of CD36.
Keywords
TNFαoxLDLqRT-PCRIFNγMsr1PPARCD36CBPDiIMDMsSTATinterferon γinterleukintumor necrosis factor αoxidized low density lipoproteinMacrophagemonocyte-derived macrophagesSignal transducer and activator of transcriptionquantitative reverse transcription polymerase chain reactionCREB binding proteincholesterolperoxisome proliferator-activated receptor γ
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Authors
Eugene M. Chu, Daven C. Tai, Jennifer L. Beer, John S. Hill,