| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302978 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 10 Pages |
Abstract
⺠ATL313 stimulates cholesterol efflux through increased expression of ABCA1 and G1 transporters. ⺠ATL313 upregulates 27-hydroxylase expression and activity, with concomitant changes in the level of oxysterols. ⺠ATL313 inhibits cholesterol influx and scavenger receptors expression ⺠ATL313 protects from lipid accumulation and foam cell formation. ⺠A2AR blockade promotes lipid accumulation and augments foam cell transformation
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Authors
Iryna Voloshyna, Steven Carsons, Michael J. Littlefield, Jayson M. Rieger, Robert Figler, Allison B. Reiss,