| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302985 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 11 Pages |
Abstract
⺠FAPP2 enables glycosphingolipid synthesis in the Golgi by transfer of glucosylceramide. ⺠FAPP2 contains a modified GLTP-fold that can also transfer other neutral glycosphingolipids. ⺠Glycolipid selectivity of FAPP2-GLTP is more focused than human GLTP. ⺠Glycolipid compartmentation appears to mute evolutionary selection pressure and divergence.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Ravi Kanth Kamlekar, Dhirendra K. Simanshu, Yong-guang Gao, Roopa Kenoth, Helen M. Pike, Franklyn G. Prendergast, Lucy Malinina, Julian G. Molotkovsky, Sergei Yu Venyaminov, Dinshaw J. Patel, Rhoderick E. Brown,