| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302986 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 9 Pages |
Abstract
⺠Mass spectrometry was used to study PE and PS trafficking to and from mitochondria. ⺠The acyl chains have a major effect on translocation of both PS and PE. ⺠KD of Mitofusin 2 and Mitostatin had no effect on PS translocation to mitochondria. ⺠Inhibition of PS synthesis by KD of PS synthase 1 markedly inhibited PS translocation. ⺠The CDP-EA and PSD pathways both contribute significantly to the PE pools of IMM and ER.
Keywords
SRMPSSOMMCDP-ethanolaminePSDESI-MSMAMLC–MSElectrospray Ionization Mass Spectrometryimminner mitochondrial membranecontact siteMass-spectrometryliquid chromatography–mass spectrometryouter mitochondrial membranemitochondria-associated membranephosphatidylcholinephosphatidylethanolaminePhosphatidylserinephosphatidylserine decarboxylasePhosphatidylserine synthasePhospholipidmethyl-β-cyclodextrinselective reaction monitoring
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Ville Kainu, Martin Hermansson, Satu Hänninen, Kati Hokynar, Pentti Somerharju,