| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8302994 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2013 | 10 Pages |
Abstract
⺠Knockout of Stard10 enhanced biliary secretion and fecal excretion of bile acids. ⺠ASBT expression was impaired in the gallbladder and small intestine of Stard10â/â. ⺠PPARα-target genes such as Cyp8b1 were down-regulated in the liver of Stard10â/â. ⺠The PPARα activity was affected by the expression of STARD10 in mouse hepatoma cells. ⺠STARD10 is involved in the PPARα-mediated regulation of bile acid homeostasis.
Keywords
GCDCATUDCACDCAHDCATLCAHprtUDCAGUDCABSEP/Bsepα-muricholic acidDCACYP27A1GlcACYP8B1AcotTCDCACYP7B1GDCATDCAacyl-coenzyme A oxidase 1PPARαTCART-PCRCpt1ataurohyodeoxycholic acidCyp4a10GCACYP7A1PPARACOX1MCA3-Hydroxy-3-Methylglutaryl-coenzyme A reductaseacyl-CoA thioesterasefarnesoid X receptorAsbtLCAsterol 12α-hydroxylasesterol 27-hydroxylaseChenodeoxycholic acidDeoxycholic acidTaurodeoxycholic acidTauroursodeoxycholic acidtaurochenodeoxycholic acidTaurolithocholic acidTaurocholic acidBile acidLithocholic acidHyodeoxycholic acidCholic acidGlycodeoxycholic acidGlycoursodeoxycholic acidGlycochenodeoxycholic acidglycolithocholic acidglycocholic acidUrsodeoxycholic acidoxysterol 7α-hydroxylaseStarstartreverse transcription-PCRrelative quantityTMCAwild typehypoxanthine-guanine phosphoribosyltransferasepolymerase chain reactionPCRmicrosomal triglyceride transfer proteinlipid transfer proteinSteroidogenic acute regulatory proteinBile salt export pumpcarnitine palmitoyltransferase 1acholesterol 7α-hydroxylasePeroxisome proliferator activated receptor
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Authors
Masanori Ito, Yoshihide Yamanashi, Yu Toyoda, Hiroko Izumi-Nakaseko, Satoko Oda, Atsushi Sugiyama, Masaru Kuroda, Hiroshi Suzuki, Tappei Takada, Satomi Adachi-Akahane,