| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303009 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 10 Pages |
Abstract
⺠FXR transactivates genes involved in bile acid, glucose and fat homeostasis. ⺠FXR negatively regulates genes (via transrepression) involved in inflammation. ⺠Therefore, side effects will probably occur when full FXR agonists are used in clinic. ⺠Post-translational modifications differentiate between transactivation/-repression. ⺠Unraveling the mechanisms of FXR signaling enables selective FXR ligand design.
Keywords
GLUT4PPARUGT2B4activation function 1α-naphthylisothiocyanateBDLSelective ligandAF1RORαSULT2A1PGC1αANITHNF4αFXRPXRLXRTransactivationChIP-SeqNCOASUMONRELBDDBDNuclear corepressorNAFLDNCoRIBABPPTMnGREFXRERAR-related orphan receptorsulfotransferase 2A1farnesoid X receptorLp(a)Non-alcoholic steatohepatitisBile acidspost-translational modificationChromatin immunoprecipitation-sequencingnon-alcoholic fatty liver diseaseTransrepressionTriglyceridesdirect repeatinverted repeatDNA binding domainligand binding domainTranscription factorLipoprotein(a)Nash Glucose transporter type 4wild typebile duct ligationliver X receptorsmall ubiquitin-like modifierAndrogen ReceptorEstrogen receptorperoxisome proliferator-activated receptorthyroid hormone receptorProgesterone receptorPregnane X receptorglucocorticoid receptorNuclear receptor
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Authors
Danielle A.A. Hollman, Alexandra Milona, Karel J. van Erpecum, Saskia W.C. van Mil,