| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303033 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 9 Pages |
Abstract
⺠Structural and functional characterization of rat and human fatty acid amide hydrolase (FAAH) ⺠Rat and human FAAH differ in their structural and functional properties. ⺠Their conformational differences might explain dissimilarities in membrane binding capability and inhibitor efficiency. ⺠The animal model alone might not be sufficient to test new drugs against FAAH-dependent human diseases.
Keywords
AEAN-stearoylethanolamineN-arachidonoylethanolamineN-oleoylethanolamineN-PalmitoylethanolaminePTGMAFPDOPCPoPCeCBsFAAH2-arachidonoylglycerol2-AGSARDPPCFFAPEAECsOEAt1/2Fatty acid amidesendocannabinoidMembrane bindingFatty acid amide hydrolaseFluorescence resonance energy transferFRETendocannabinoidsisopropyl-β-d-thiogalactopyranosideSeadioleoylphosphatidylcholinecircular dichroismendocannabinoid systemFluorescence
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Authors
Almerinda Di Venere, Enrico Dainese, Filomena Fezza, Beatrice Clotilde Angelucci, Nicola Rosato, Benjamin F. Cravatt, Alessandro Finazzi-Agrò, Giampiero Mei, Mauro Maccarrone,