| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303053 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 7 Pages |
Abstract
⺠CYP7B1 substrates activate the androgen receptor (AR) in a cell line-specific way. ⺠Corresponding CYP7B1-formed products are less able to activate AR. ⺠CYP7B1 substrates but not CYP7B1-formed products stimulate androgen target genes. ⺠CYP7B1-mediated metabolism may decrease or abolish androgenic signalling.
Keywords
dehydroepiandrosteroneFK506 binding protein 5CYP7B1SMRTSRC-1DHEA17β-Hydroxysteroid dehydrogenaseFKBP517β-HSDTLC4-MACyPPSADHT5-androstene-3β,17β-diol5α-androstane-3β,17β-diolAndrogenEnzyme-linked immunosorbent assayELISASraDihydrotestosteroneCytochrome P450androgen response elementSteroid metabolismAREHydroxylationprostate-specific antigenthin layer chromatographyAndrogen Receptor
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Authors
Johan Lundqvist, Maria Norlin,