| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303081 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 7 Pages |
Abstract
⺠Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking via type-1 S1P receptor (S1P1). ⺠We developed a novel type S1P1-selective antagonist, TASP0251078. ⺠TASP0251078 induces lymphocyte sequestration from circulation and suppresses immune responses. ⺠TASP0251078 will be highly beneficial for the development of immunosuppressive drugs.
Keywords
Sphingosine 1-phosphate (S1P)S1PHEK293S1P1IC50CHO-K1CHSTNCBHEPESGTPHTSTC502,4,6-trinitrochlorobenzeneBSAcAMPguanosine-5′-triphosphateN-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acidCyclic adenosine monophosphatebovine serum albuminsphingosine 1-phosphateEIAEnzyme-linked immunosorbent assayGDPhuman embryonic kidney cell lineImmunosuppressive agenthigh-throughput screeninglymphopeniahalf maximal (50%) inhibitory concentrationChinese Hamster Ovary cell lineChemotaxisguanosine-5′-diphosphate
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Authors
Yasuyuki Fujii, Hidenori Ohtake, Naoya Ono, Toshifumi Hara, Takanobu Sakurai, Syuya Takahashi, Tetsuo Takayama, Yoshiki Fukasawa, Fumiyasu Shiozawa, Narutoshi Tsukahara, Takehiro Hirayama, Yasuyuki Igarashi, Ryo Goitsuka,