| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303082 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 11 Pages |
Abstract
⺠LPS treatment induces triglyceride synthesis and LD formation in microglia. ⺠LPS treatment leads to activation of p38 and JNK MAPKs. ⺠Perilipin-2 expression is increased following LPS treatment. ⺠Inhibition of p38 blocks LD accumulation and perilipin-2 expression. ⺠Cytosolic phospholipase A2-α colocalizes with LPS-induced LDs.
Keywords
LPSJnkPI3KTLR4ADRPFFAAP-1c-Jun N-terminal kinaseMAPKMAPK kinaseMKKOleic acidFree fatty acidtriglycerideCNScentral nervous systemPhosphatidylinositol 3-kinaseMicroglia activationLipid dropletslipid dropletLipopolysaccharidesNitric oxideactivator protein-1Adipocyte differentiation-related proteinmitogen-activated protein kinasesToll-like receptor 4
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Authors
Armen Khatchadourian, Simon D. Bourque, Vincent R. Richard, Vladimir I. Titorenko, Dusica Maysinger,