| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303088 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 12 Pages |
Abstract
⺠We functionally characterized a fatty acyl desaturase and elongase in sole. ⺠Fad has Î4-activity and Elovl has substrate specificity typical of fish Elovl5. ⺠Sole appears able to synthesize DHA from EPA via a Sprecher-independent pathway. ⺠Î4fad and elovl5 showed a marked pattern of regulation during early ontogenesis. ⺠Î4fad shows nutritional regulation, up-regulated in response to LC-PUFA-poor diets.
Keywords
Solea senegalensisEPADAHDPALC-PUFAEFAALAORFα-linolenic acidArachidonic acidEicosapentaenoic aciddocosapentaenoic aciddocosahexaenoic acidLinoleic acidFatty acidEssential fatty acidLong-chain polyunsaturated fatty acidsOntogenesisMarine teleostrapid amplification of cDNA endsTranscriptional regulationARADHAdays after hatchingopen reading frameFAME یا fatty acid methyl esters fatty acid methyl estersLoARacepolymerase chain reactionPCR
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Authors
Sofia Morais, Filipa Castanheira, Laura Martinez-Rubio, Luis E.C. Conceição, Douglas R. Tocher,