| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303158 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 9 Pages |
Abstract
⺠Holo-RBP, which transports vitamin A in blood, is a signaling molecule. ⺠STRA6 functions both as a vitamin A transporter and as a surface signaling receptor activated by holo-RBP. ⺠Activation of STRA6 by RBP-ROH triggers a JAK/STAT cascade, thereby inducing gene trascription. ⺠Some genes induced by RBP-ROH/STRA6/JAK/STAT signaling are involved in regulating insulin responses and lipid metabolism.
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Authors
Daniel C. Berry, Noa Noy,