| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303167 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 13 Pages |
Abstract
⺠Treatment with all-trans retinoic acid reduces body fat and improves insulin sensitivity in mice by promoting fat mobilisation and catabolism. ⺠Retinoid-induced hypertriglyceridemia is, however, frequently encountered in humans and animal models. ⺠There is an intimate cross-talk between retinoid and lipid metabolism. ⺠Molecular mechanisms of retinoid effects on lipid metabolism are complex and not fully understood.
Keywords
HSLCPT1CRABP-IILPLVLDLAMPKRARRXRChREBPDNLPGC-1LXRACOXacyl-CoA oxidaseFABP5SREBP-1MCADUCPBCMO1RaldTTNPBcarnitine/acylcarnitine carrierBATACCCACFASRetinoid X receptorPPARPRBAMP-activated protein kinaseatRAC/EBPp38 MAPKAdipogenesisall-trans retinoic acidPPREde novo lipogenesisacetyl-CoA carboxylasefatty acid synthaseWhite adipose tissuebrown adipose tissueThermogenesisRALDHretinaldehydeRetinaldehyde dehydrogenaseRetinoic acidMedium-chain acyl-CoA dehydrogenasePPAR response elementretinoic acid response elementhormone sensitive lipaseLipoprotein lipaseLipolysisvery low density lipoproteinLipogenesisObesityRARECCAAT-enhancer binding proteincarbohydrate response element binding proteinUncoupling proteinretinoblastoma proteinSterol regulatory element binding protein-1p38 mitogen-activated protein kinaseWATCarnitine palmitoyltransferase 1liver X receptorRetinoic acid receptorperoxisome proliferator-activated receptor
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Authors
M. Luisa Bonet, Joan Ribot, Andreu Palou,