| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303180 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 8 Pages |
Abstract
⺠This review focuses on the enzymes that convert vitamin A (retinol) to retinoic acid. ⺠Alcohol dehydrogenases and retinol dehydrogenases convert retinol to retinaldehyde. ⺠Retinaldehyde dehydrogenases metabolize retinaldehyde to retinoic acid. ⺠We discuss mouse models carrying loss-of-function mutations for these enzymes. ⺠These mouse models have been instrumental for understanding vitamin A function.
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Authors
Sandeep Kumar, Lisa L. Sandell, Paul A. Trainor, Frank Koentgen, Gregg Duester,