Retinoid metabolism and its effects on the vasculature

Article ID	Journal	Published Year	Pages	File Type
8303198	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2012	11 Pages	PDF

Abstract

âº Retinoids, derivatives of vitamin A, control fundamental cellular processes. âº In this review, we examine the complex effects of retinoids on the vasculature. âº Retinoids modulate vascular injury, inflammation, and thrombosis in atherogenesis. Further work is needed to define the scope of retinoid effects on vascular disease.

Keywords

PPAR MGP HDAC RAR MIR NOS LXR iNOS HUVEC Phorbol-12-myristate-13-acetate Rald eNOS FXR AP-1 OPG PAI-1 PDGF PKC GM-CSF KLF LPS RARRES1 ARVM CYP26 DBD CRBP ADMA LBD RANKL CRABP CMEC bFGF CARET ATBC ADH atRA farnesoid X receptor PMA all-trans retinoic acid Osteoprotegerin Alcohol dehydrogenase interleukin coronary artery disease ESC DNA binding domain ligand binding domain asymmetric dimethylarginine RALDH retinaldehyde Retinaldehyde dehydrogenase Retinoic acid Human umbilical vein endothelial cell Dendritic cell Embryonic stem cells inducible nitric oxide synthase endothelial nitric oxide synthase CAD granulocyte-macrophage colony-stimulating factor retinoic acid response element platelet-derived growth factor basic fibroblast growth factor activated protein-1 lipopolysaccharide major histocompatibility complex MHC Plasminogen activator inhibitor-1 mitofusin 2 adult rat ventricular myocytes MicroRNA RARE Prime nitric oxide synthase Histone acetyltransferase histone deacetylase Matrix Gla protein cellular retinol binding protein cellular retinoic acid binding protein C-reactive protein CRP Protein kinase C liver X receptor HAT Retinoic acid receptor peroxisome proliferator-activated receptor