Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice

Article ID	Journal	Published Year	Pages	File Type
8303213	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2011	9 Pages	PDF

Abstract

âº Over-expression of RBP4 leads to insulin resistance and fatty liver in HFD mice. âº RNA oligonucleotide targeted at RBP4 ameliorates metabolic syndrome in HFD mice. âº Anti-RBP4 RNA oligonucleotide reduces liver fat and improves hepatic steatosis.

Keywords

RBP4 AOC IPITT NEFA RSG GLUT4 NAFLD PEPCK HFD AUC IPGTT intraperitoneal glucose tolerance test non-esterified fatty acids non-alcoholic fatty liver disease triacylglycerol TAG یا triacylglycerols glucose transporter 4 rosiglitazone High fat diet Metabolic syndrome phosphoenolpyruvate carboxykinase Areas under the curve Retinol-binding protein 4