| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303216 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 11 Pages |
Abstract
⺠CLnA inhibited viability and cell growth of HT-29 more effective than CLA. ⺠All trans-CFAs were more effective compared to cis/trans-CFAs. ⺠Investigation of genes revealed absence of â5-/â6-desaturases and elongases. ⺠This study confirmed conversion of CLnA isomers to CLA isomers. ⺠The conversion of CLA (t11,t13) into another CLA isomer (c9,t11) was shown.
Keywords
SFAConjugated fatty acidPLA2G4AFADS1ELOVL6ELOVL2FADS2CEPAHT-29ELOVL5arachidonate 5-lipoxygenaseALOX5Ptgs2PGE2EC50CLACFAPBSFBSSCDCLnA50% effective concentrationconjugated linolenic acidconjugated linoleic acidsaturated fatty acidfatty acid synthasePolyunsaturated fatty acidPUFAConversionColorectal cancerfetal bovine serumcolon cancer cellHuman colon adenocarcinoma cellsFasnPhosphate-buffered salineProstaglandin E2CRC
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Authors
Christian Degen, Josef Ecker, Stefanie Piegholdt, Gerhard Liebisch, Gerd Schmitz, Gerhard Jahreis,