Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis

►Hepatic CTα knockout mice are susceptible to high fat diet-induced liver NASH. ►Hepatic CTα knockout mice have 25% lower hepatic PC resulting in steatosis. ►Diacylglycerol and ceramide are elevated by 50% in CTα-deficient livers. ►Normalization of hepatic PC prevents steatosis in hepatic CTα knockout mice. ►Hepatic level of PC is not the only determinant for the development of NASH.