| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303232 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 9 Pages |
Abstract
⺠Acyl-serotonins are endogenously present in the gastro-intestinal tract. ⺠Incubation of ileal tissue with serotonin elevated the levels of acyl-serotonins. ⺠N-acyl-serotonin patterns in the intestine is related to fatty acids in the diet. ⺠N-acyl-serotonins are able to inhibit GLP-1 secretion and FAAH activity in vitro.
Keywords
MRMAA-5-HTOLDAN-arachidonoyl dopamineHoSFarachidonoyl ethanolamideFAAHGLP-1CB1PPARαAmCNAEsTFASPEAEAEPATRPV1LLOQCIDTHFCollision-induced dissociationSolid phase extractionFatty acid amide hydrolaseEicosapentaenoic acidTrifluoro acetic aciddocosahexaenoic acidTetrahydrofuranlower limit of quantificationGastro-intestinal tractDHAFish oillactate dehydrogenaseLDHLodlimit of detectionNADAglucagon-like peptide-1quality controlperoxisome proliferator-activated receptor
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Authors
Kitty C.M. Verhoeckx, Trudy Voortman, Michiel G.J. Balvers, Henk F.J. Hendriks, Heleen M.Wortelboer, Renger F. Witkamp,