| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303234 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 10 Pages |
Abstract
⺠StarD4 is a START domain protein with a cholesterol-specific lipid binding pocket. ⺠StarD4 is found in hepatocytes, macrophages and fibroblast in the cytoplasm and ER. ⺠StarD4 is regulated by sterols and upregulated during macrophage differentiation. ⺠The protein is able to increase ACAT activity in an in vitro assay. ⺠StarD4 is a highly regulated, non-vesicular, directional cholesterol transporter.
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Authors
Daniel Rodriguez-Agudo, Maria Calderon-Dominguez, Shunlin Ren, Dalila Marques, Kaye Redford, Miguel Angel Medina-Torres, Phillip Hylemon, Gregorio Gil, William M. Pandak,