| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303251 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 8 Pages |
Abstract
âºUsing apoAI- and apoAI-CIII-AIV-transgenic mice we have investigated regulation of fenofibrate-induced regulation of apoAI gene expression in AI and AI-CIII-AIV transgenic mouse lines. ⺠Fenofibrate up-regulates apoAI gene in apoAI transgenic mice, but not in apoAI-CIII-AIV transgenic mice. ⺠Cholic acid down-regulates apoAI gene expression both in apoAI and apoAI-CIII-AIV transgenic mice. ⺠Fenofibrate and cholic acid regulate SR-BI gene expression in opposite direction, which may be partly responsible for circulating levels of HDL-C. ⺠Fenofibrate up-regulated sterol career protein 2, suggesting increased delivery of cholesterol to the liver. ⺠Fenofibrate increased HDL size both in the apoAI and AI-CIII-AIV transgenic mice via up-regulation of the PLTP gene.
Keywords
ACCSCP2PLTPFPLCHDLFASSR-BIACOPPARHDL-CHAIapoapolipoproteinApolipoprotein A1acetyl coA carboxylasefatty acid synthaseCholic acidTriglyceridesfast protein liquid chromatographyFenofibratehigh-density lipoprotein cholesterolPhospholipid transfer proteinPeroxisome proliferator activated receptorscavenger receptor class B type I
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Authors
Rai Ajit K. Srivastava, Shirley He, Roger S. Newton,