| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303258 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 13 Pages |
Abstract
⺠Brown spider recombinant toxin hydrolyzes sphingomyelin. ⺠Catalytic site-directed mutagenesis H12A reduces drastically substrate hydrolysis. ⺠Dermonecrosis and inflammation induced by toxin depend on phospholipase activity. ⺠Both recombinant forms bound to lipids in blot and endothelial cell membrane. ⺠Phospholipase-D activity induces endothelial citotoxicity. ⺠Lysophospholipids and glycerophospholipids are also substrates for LiRecDT1.
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Authors
Olga M. Chaim, Rafael B. da Silveira, Dilza Trevisan-Silva, Valéria P. Ferrer, Youssef B. Sade, Mariana Bóia-Ferreira, Luiza H. Gremski, Waldemiro Gremski, Andrea Senff-Ribeiro, Hélio K. Takahashi, Marcos S. Toledo, Helena B. Nader, Silvio S. Veiga,